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The final concentration is 1 mg per ml

For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative

Likewise, autoimmune conditions that affect the stomach lining, such as atrophic gastritis or pernicious anemia, directly impact intrinsic factora protein essential for B12 absorption

The likely direction is that undiagnosed disease raises B12, not that B12 causes the disease