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Four groups of 20 participants each were formed: the first group received an oral L-carnitine supplement, the second applied a topical lotion containing L-carnitine, the third combined both the supplement and the lotion, and the fourth served as the untreated control group

In addition, activation of GLP-1R regulates mitochondrial over fission by the cAMP/PKA pathway while improving mitochondrial function in A-treated astrocytes and ameliorating pathological lesions in AD (Xie et al., 2021)

Research published in Frontiers in Immunology demonstrated that these patients show reduced microbial diversity, decreased populations of beneficial bacteria (including Lactobacillus and Bifidobacterium species), and increased intestinal permeability, commonly known as leaky gut

But specific situations call for different approaches