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For superoxide anion, the main ROS, a first line of defense is represented by the enzyme superoxide dismutase, localized in the mitochondrial matrix
For progressive forms, such as secondary progressive MS (SPMS) and primary progressive MS (PPMS), therapeutic options are limited compared to relapsingremitting MS (RRMS) [141]
Cu - the copper Your body needs copper - the enzymes that cross-link collagen into strong connective tissue don't work without it - but loose copper is reactive enough to damage cells, so the body keeps almost none of it drifting around free
Night shift work-related breast carcinogenesis: mechanistic pathways and biomarker discovery The etiopathogenesis of BC in the context of NSW is increasingly understood through mechanistic studies that explore the biological consequences of circadian disruption 37
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