The submission is supported by the SURPASS CVOT trial, which showed that Mounjaro reduced the risk of MACE including cardiovascular (CV) death, heart attack, or stroke by 8% compared with dulaglutide (Trulicity
Levocarnitine is an amino-acid derivative essential for mitochondrial fatty-acid transport, and this injectable formulation is used to treat or prevent clinically significant carnitine deficiency in conditions such as primary systemic carnitine deficiency, certain inborn errors of metabolism, and end-stage renal disease on dialysis
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
While anyone can benefit from Vitamin B12 injections, theyre particularly valuable for: A healthcare professional diagnoses individuals with B12 deficiencies