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Retatrutide binds three receptors: the GLP-1 receptor (regulates appetite, insulin secretion, and gastric emptying), the GIP receptor (influences insulin response and adipose handling), and the glucagon receptor (affects energy expenditure and hepatic lipid handling)
It plays a key role in functions like tissue building, protein synthesis, chemical production, and immune strengthening
Tirzepatide and semaglutide are both FDA-approved weekly injections for weight management and type 2 diabetes
Less commonly, some users experience the opposite, constipation
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