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ChaC2 induces mitochondrial apoptosis and autophagy via UPR, serving a pivotal role as a tumor suppressor gene in the onset, proliferation and metastasis of gastric and colorectal cancer (79)

Additionally, IS levels are influenced by dietary protein intake (particularly aromatic amino acids), gut transit time, and medications (phosphate binders, antibiotics)

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Choline is essential for transporting fats from the liver, preventing fatty liver, and ensuring that fats are burned for energy rather than stored