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The authors hypothesized that an increasing GSH concentration represents an adaptive mechanism to increase antioxidant defenses, which results in fewer symptoms, reduced airway reactivity, and milder disease in patients with asthma

A simple way to avoid the issue is to take creatine with food, avoid loading phases, or take multiple smaller doses (3-5 grams) during a loading phase

However, the negative redox potential of roGFP2, the instantaneous nonenzymatic formation of roGFP2(S 2 ) from roGFP2(SSG), and the very slow nonenzymatic reaction of roGFP2(S 2 ) with GSH make the nonenzymatic shortcut from Fig

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