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If a patients expectation is that a weekly injection will produce weight loss without dietary change, the ethical move is to reset the expectation or decline the treatment not to sell the package

A 2025 European Journal of Clinical Nutrition commentary on the NICE guideline argued that the diagnostic threshold and clinical awareness still need to be tightened further, especially around pernicious anaemia, which is still under-recognised in primary care

For those with a personal or family history of diabetes, high blood pressure, blood vessel disease, or high blood sugar, semaglutide treatment should always be monitored by a qualified medical professional

Additionally, scientists examine its influence on chondrocyte activity in vitro