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While MT1 does not exhibit the same appetite-regulating effects, it may still contribute indirectly to weight management by promoting overall well-being and physical activity through improved energy levels and vitality

they may also vary depending on the physician doing the scoring

A Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) reported that participants receiving higher doses of retatrutide (up to 12 mg) achieved mean body weight reductions of approximately 1724% over 48 weeks

Retatrutide shows a more favorable side effect profile in Phase 2 data, with lower nausea and discontinuation rates