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When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself
Hormonal imbalances can trigger weight gain or resistance to weight loss, while excess weight can disrupt hormone levels, potentially leading to hormone imbalance and metabolic disorders
One trial evaluated placebo vs canagliflozin 300mg vs phentermine 15mg, vs combination phentermine/canagliflozin in obese and overweight patients without diabetes
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