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The macrocycle spans residues AspLys via a side-chain lactam, producing a conformationally constrained ring that distinguishes it structurally from linear -MSH precursors
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Note that the minor degree of weight loss in all groups is commonly seen with the implantation of osmotic minipumps due to nonspecific stress 50
Some individuals also report experiencing relief from seasonal allergies, sinusitis, and upper respiratory tract infections
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