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The dosage of AOD9604 used in this study or 0.25 mg per injection, was carefully calculated to be molar equivalent to doses of full-length GH shown to be effective in prior rabbit OA studies

This is because glutathione deficiency contributes to oxidative stress, which plays a key role in these and other disease pathogenesis such as seizures, Alzheimers disease, liver disease, sickle cell anemia, cancer, heart attack, stroke, and diabetes