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In GLP-1R -/- mice, lack of GLP-1R expression in adipocytes caused a reduction in adipogenesis, through the induction of apoptosis in pre-adipocytes by inhibiting ERK, PKC, and AKT signaling pathways (50) ( Figure 2 )

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In an in vitro model system, a cumulative 26% of the supplemented apigenin was absorbed by intestinal epithelium over 240 min and extensive phase I and II metabolism occurred yielding apigenin metabolites, mainly apigenin-7-sulfate, attributing to apigenins low overall bioavailability [152]