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One moderate interaction to note is that oral B-complex vitamins, including riboflavin, can interfere with the absorption of tetracycline antibiotics if taken simultaneously

Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions

The combination remains speculative but represents logical stacking based on mechanism understanding

The safety profile of AOD-9604 is favorable compared to many metabolic interventions, with clinical trials involving approximately 900 participants demonstrating good tolerability and minimal side effects