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It is used in laboratory studies of multi-receptor agonist design, energy expenditure separate from energy intake, hepatic lipid and glucose handling under glucagon receptor engagement, and as a benchmark against single and dual receptor agonists

The variability found in our results is also consistent with RCT results demonstrating a continuum of effects - while overall ETD for weight loss was attenuated in our study, the RCTs for semaglutide and tirzepatide have also shown that between 9-14% of patients lost less than 5% of body weight over 12 months, and between 16-33% lost less than 10%

This rate of weight loss helps to prevent side effects of weight loss like hair loss, muscle loss, and nutrient deficiencies

Phase 2 Type 2 Diabetes (Oral + Subcutaneous) Published: November 2025 Participants: 448 adults with T2D on metformin SGLT2i Duration: Up to 36 weeks Results: - Once-weekly subcutaneous amycretin: up to 14.5% weight loss (vs