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The 5 mg formulation typically represents an intermediate titration dose used to evaluate patient response and minimize gastrointestinal side effects during dose escalation in clinical studies

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477 proteins were found to be differentially expressed (Supplemental Table 1), of which 302 proteins had a minimum fold change of 1.2 (Supplemental Table 2)

The researchers compared their outcome with patients who received other antidiabetic medications, including insulin, metformin, dipeptidyl-peptidase-4 inhibitors, sodium-glucose cotransporter-2 inhibitors, sulfonylureas, thiazolidinediones and other GLP-1 receptor agonists like liraglutide