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Patients who maintain their dose and lifestyle changes sustain weight loss for years, while those who discontinue without establishing new habits often regain weight within 612 months

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Semaglutide, primarily known for its use in managing type 2 diabetes, has drawn attention to its potential effects on gout symptoms

The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc