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Some people may also experience a placebo effect, feeling an immediate improvement simply because they expect to

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GLP1/E therapy also elicited specific changes in the hypothalamic proteomic profile in PNA mice, upregulating proteins involved in the metabolism of non-coding RNA, signaling of nuclear receptor and estrogen-dependent gene expression and downregulating pathways involved in apoptosis, signaling by insulin receptor and cellular responses to starvation

They are also checking for insulin resistance, hormone patterns, and other clues that might respond better to a GLP-1-only or a dual-incretin approach