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Encapsulating rapamycin within poly (lactic-co-glycolic acid) (PLGA) nanoparticles for targeted delivery not only enhances rapamycins water solubility and bioavailability but also significantly reduces the expression of drug-resistance-related genes, such as mTOR and Bcl-2, in bladder cancer cells, thereby increasing apoptosis rates and drug sensitivity (48)
However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies
Mice were placed in an NMR analyzer (Minispec, IF90II, Bruker Optics GmbH
When dealing with acute episodes, it's important to adhere to common anaphylaxis treatment recommendations until the patient stabilizes and other treatments can resume
