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Important safety considerations include risks of pancreatitis, gallbladder disease, worsening of diabetic retinopathy (particularly with rapid improvement in blood glucose), and potential kidney injury if dehydration occurs due to gastrointestinal side effects

These concerns are not unfounded, as the medications mechanismslowing gastric emptying and altering hormone levelscould theoretically impact bile flow and composition, potentially leading to gallbladder complications

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