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Journal of Neurochemistry , 114(3), pp.820831

Increasing the dose to compensate for poor absorption is an inefficient and unreliable research method

610,611,612 Inhibiting complex I activity and supercomplex formation through depletion of methylation-controlled J (MCJ) protein enhances mitochondrial function and boosts ATP synthesis in the remnant liver

However, since the tubular reabsorption occurs via an active transporter, once the transporter is saturated by the high plasma L-carnitine concentrations achieved by intravenous administration, the circulating L-carnitine is rapidly excreted