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Heavy metals are also known to induce mitochondrial dysfunction, deplete antioxidant reserves, and alter immune signaling pathways like NF-B and AP-1, all of which amplify inflammatory responses (Korashy et al., 2008
Kuznetsov AV, Margreiter R, Ausserlechner MJ, Hagenbuchner J
The SN experiences an increase in free iron content and a drop in paramagnetic NM-iron complex level with neuronal death and NM depletion
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