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Activation of NF-B occurs post-ischemia, and blocking the activation of NF-B can help mitigate inflammatory damage (41)

Regarding weight reduction, pooled results from clinical trials indicate that, compared to placebo, liraglutide at 3.0 mg/d achieves a placebo-subtracted weight loss of approximately 5%

Specifically, compared with persisting GLP-1RA, the addition of basal insulin by either free up-titration or FRC caused an additional decrease of 0.75% and 36.3 mg/dl in HbA1c and FPG, respectively, and a 7.59 times higher risk of hypoglycemia in 26 weeks

The cardiovascular safety profile makes GLP-1 medications particularly attractive for people with diabetes who also have heart disease risk factors