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The underreported symptoms are leads that came from patients themselves, unprompted, and clinicians could potentially pay attention to them. Commonly reported side effects include gastrointestinal symptoms such as nausea, vomiting, and diarrhea, which have all been established in clinical trials and regulatory documents and have been extensively reported on

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This may be another positive factor for clinicians when selecting appropriate treatment for a patient with cardiovascular risk and a history of smoking, excess drinking, or other SUD

Notably, Gclc KO mice rapidly lose weight and reach humane endpoints early (Fig