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A 2021 study published in the New England Journal of Medicine showed that people on semaglutide lost 14.9% of their body weight over 68 weeks versus 2.4% in the placebo group
People with very high starting weights may lose more in the initial weeks due to water weight shifts, but this rapid loss does not reflect actual fat loss and does not continue at the same rate
The supernatant was then transferred to a fresh tube, and total GLP-1 levels were measured via an ELISA kit (EZGLP1T-36K, Millipore, Tokyo, Japan) following the manufacturers instructions
Until official regulatory approval is granted, there is no approved maximum dose for clinical use
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