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Method development must also address the sensitivity of semaglutide retention to pH (optimal stability at pH 7.4-7.8 per formulation data
The mechanism of delayed gastric emptyingwhile therapeutically beneficial for glycemic control and appetite reductiondirectly affects the gastrointestinal tract and is responsible for many of the digestive side effects associated with semaglutide
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The 1 Da mass difference (water addition) is resolvable on most research-grade mass spectrometers
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