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However, the authors suggested that carnitine deficiency cannot be the only reason for fatal VHT, because a 3.5-year-old girl developed hepatic failure under VPA therapy despite normal serum carnitine values, and died despite oral L-carnitine supplementation

It mimics the GLP-1 hormone causing a delay in gastric emptying, resulting in patients feeling fuller longer

In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

The analog retains full IGF-1 receptor (IGF-1R) agonist activity while displaying extended bioactivity in cell culture and rodent research models