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The most frequent adverse effects are gastrointestinal and dose-related: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort - Typically worst during dose escalation and often resolve or attenuate with continued treatment and slower titration

Legend may help: Improve joint lubrication and fluid quality Decrease inflammation within the joint Reduce lameness associated with joint irritation Support smoother, more comfortable movement Legend may be administered intravenously (IV) or directly into the joint (IA) depending on the condition being treated

Faster return to running through effective treatment carries significant practical value for serious runners

Tirzepatide's dual incretin agonism produces the most robust weight reduction of any GLP-1-based therapy to date