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Berry SH, Elliott MN, Suttorp M et al: Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the united states

These effects are well-documented across clinical trials: The good news is that these effects follow a predictable timeline

When the inflammatory burden is high from insulin resistance, dyslipidemia (high LDL/triglycerides), high blood pressure, and liver stress it drives cholesterol particles into the artery lining and triggers the plaque buildup that can eventually rupture and cut off blood flow to the heart

The scale weight they lost by stopping creatine was water, not fat