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The fact that the venom is used towards members of the same species during the mating season may have favored the use of the endogenous gene as the most effective venom component
The expression of the E3 ubiquitin ligase TRIM3 is significantly reduced in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which are predominant subtypes of non-small cell lung cancer (NSCLC), but overexpression of TRIM3 can increase ROS levels and LPO in cancer cells, promoting ferroptosis[77]
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