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--- 4 Pharmacokinetics Parameter Detail Absorption Well absorbed orally Bioavailability ~100% Peak Plasma Time 34 hours Half-life ~70 hours (once daily dosing) Metabolism Liver (CYP2D6 & CYP3A4) Excretion Urine (major), feces Long half-life Once daily dosing

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Residual oxygen consumption was established by addition of the inhibitor antimycin A (2.5 mM) and the resulting value was subtracted from the fluxes in each run, to correct for non-mitochondrial respiration

The most common way to take semaglutide is through a once-weekly injection, performed at home after a quick training session