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Dec 29, 2025 Cagrilintide is a long-acting amylin receptor agonist that produces 10-12% body weight loss through mechanisms completely different from GLP-1s - dramatically slowing gastric emptying, suppressing appetite via brain amylin receptors, and reducing postprandial glucose

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8 Challenges, limitations, and future directions Despite significant advances in understanding how the gut, immune system, and brain interact in PD, several challenges limit the translation of these insights into clinical practice