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They produce measurable pharmacological effects in humans, and ipamorelin has also been evaluated in a phase II clinical trial
Transcriptomic data reveal upregulation of lipogenic genes and TAG synthesis enzymes, alongside increased intracellular TAG and lipid scavenging receptors like crq
Several alternatives target tissue repair through different mechanisms
In parallel, oxidative stress contributes to pathogenesis through an imbalance between pro-oxidant and antioxidant systems, promoting cellular injury and immune dysfunction
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