surmount-1 trial tirzepatide non-diabetic obesity weight loss 🤔Adults with type 2 diabetes and lose less on EVERY GLP-1 drug compared to those without diabetes, consistently ~5% less. Now that we have retatrutide's TRIUMPH-2 data today we can SURMOUNT-1 Trial Summary: What Tirzepatide

These are similar to those used for travel sickness and work by calming the digestive muscles and affecting the brains nausea centre

Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

Both are powerful injectable medications that act on hormones affecting blood sugar control and appetite regulation

A critic to the use of a murine model deficient for intestinal GCG products, would be that other gut hormones might compensate for the lack of a functional GCG gene in that tissue, hence explaining the normalized incretin effect