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Last but not least, L-carnitine has been shown to reduce both mental and physical fatigue during exercise in the elderly, but not in young, healthy people
Historically described as mere fat-solubilizing agents, these amphipathic compounds were recently recognized as key signaling molecules capable to modulate the host metabolism directly acting as ligands of intestinal GPCRs (338, 339), or after being metabolized by the colonic microbiota into secondary bile acids, mostly deoxycholic and lithocholic acid(340)
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