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Insulin/IGF-1/FoxO signaling and acne Acne is epidemic in adolescents of Western life style and absent in populations consuming a Paleolithic diet excluding sugar, grains and dairy like the Kitava islanders who exhibit low basal insulin levels compared with age-matched Europeans [15]
While both GLP 1 & GIP therapy and GLP 1s are GLP-1 receptor agonists that help with weight loss, GLP 1 & GIP therapy also includes a second mechanismGIP receptor activationwhich enhances its effectiveness
10.1038/373702a0 116 VanhaesebroeckB.JonesG
This last factoid suggests it likely wouldnt work as well in younger patients who already have maximally sensitive HGH receptors on their cells
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