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Maintaining open communication between all your healthcare providers prevents dangerous gaps in monitoring or contradictory treatment recommendations

Neurological benefits including improved outcomes in demyelinating disease models point to CNS effects

This broad receptor distribution has prompted investigation into potential pleiotropic effects beyond glycemic control, including cardiovascular protection, renal benefits, and anti-inflammatory properties

Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)