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FOXO transcription factors play a crucial role in the regulation of processes related to aging and longevity, with increasing evidence suggesting their significance in the pathogenesis of neurodegenerative diseases (NDDs)

They are generally recommended for those with a BMI of 27 or higher with weight-related health conditions, or a BMI of 30 or higher

If the safety and modest efficacy data from the published trials translate to our patient population, it would give us a tool that acts directly on fat cell metabolism rather than appetite, with a side effect profile that appears extremely well-tolerated