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6,7 Unless contraindicated, metformin with lifestyle modifications remain first line therapy
This year, as the dust of the years-long GLP-1 boom started to settle (albeit gradually), an important narrative around obesity came into view: Health is not just about personal choices, but also a complex mix of biology and genetics
employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor (ROR) (ROR-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via ROR-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28]
m Yoneda Y, Ogita K, Kouda T, Ogawa Y
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