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Although no data from head-to-head trials comparing retatrutide to other currently approved obesity treatments exist, data from the phase 2 studies with retatrutide suggest that at higher doses, retatrutide could lead to greater WL compared to the most efficacious approved treatments for obesity and T2D such as tirzepatide 15 mg and semaglutide 2.4 mg (Fig
As a synthetic 39-amino acid peptide, Retatrutide acts as a single-sequence multi-agonist with targeted structural affinity for three distinct metabolic pathways: the Gastric Inhibitory Polypeptide (GIP) receptor, the Glucagon-Like Peptide-1 (GLP-1) receptor, and the Glucagon receptor (GCGR)
The experienced weight
