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Because oral glutathione supplements have historically demonstrated poor bioavailability and are rapidly broken down by enzymes in the gastrointestinal tract, the body relies heavily on intracellular de novo synthesis to maintain its protective antioxidant pools

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Furthermore, treatment with Pluronic L-81, a surfactant that inhibits chylomicron formation, significantly attenuates the anorectic effects of intraduodenal lipids and attenuates both CCK release and celiac and cervical vagal afferent activation following lipid infusion 40,109,156,186

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