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In terms of duration of action, exenatide and lixisenatide are considered short-acting GLP-1 receptor agonists with a half-life of approximately 25 h, while dulaglutide, liraglutide and exenatide-LAR are considered long-acting GLP-1 receptor agonists with a half-life of 12 hseveral days
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Accumulation of krebs cycle intermediates and over-expression of hif1alpha in tumours which result from germline fh and sdh mutations
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