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These occur mainly due to circulatory disturbances, increased capillary leakage, and fluid accumulation ( 1.2.5 Complications and their risk Severe cases of high altitude illness can lead to potentially fatal complications: High Altitude Pulmonary Edema (HAPE): HAPE is non cardiogenic pulmonary edema caused by acute severe hypoxia, which leads to pulmonary vein vasoconstriction, causing a sharp increase in pulmonary arterial pressure, local hyperperfusion, increased pulmonary blood flow, and imbalanced ventilation blood flow ratio

"Triple-Hormone-Receptor Agonist Retatrutide for Obesity." NEJM 2023;389:514526

doi: 10.1016/S0140-6736(21)02758-6 4 AboudounyaM

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