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Clinical trials used doses as high as 1 mg per day without safety concerns, but 300 mcg is the most commonly referenced dose in peptide medicine literature and in the investigational protocols that have been published since the formal trials concluded
Unfortunately, many people are vitamin B12 deficient, especially those who follow a vegetarian or vegan diet
But even some people who eat meat might not absorb it very well
A deficiency in B12 can lead to a significant decrease in energy and exercise tolerance, along with fatigue
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