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Low doses of peripheral Ex-4 (0.1 and 0.2 g/kg) reduced cocaine priming-induced reinstatement of cocaine-seeking behavior dose-dependently but did not affect chow food intake, meal patterns, and body weight (Hernandez et al., Cocaine-experienced rats had greater plasma corticosterone levels, and corticosterone administration into the hindbrain fourth ventricle reduced cocaine self-administration dose-dependently without changing sucrose intake, and these effects were inhibited by GLP-1 antagonist (Schmidt et al., In the LS slices, GLP-1 increased DAT surface expression (increased transport capacity), and DA uptake and GLP-1 antagonist reversed these effects

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Cowan S, Lim S, Alycia C, Pirotta S, Thomson R, Gibson-Helm M et al (2023) Lifestyle management in polycystic ovary syndrome beyond diet and physical activity

For motivated patients, some services allow patient-specific direction so they can self-administer B at home (after training)