At present, retatrutide is administered exclusively as a subcutaneous injection, meaning it is injected under the skin, typically in the abdomen, thigh, or upper arm
Even with lifestyle changes like diet and exercise, it can be extremely difficult to meet those benchmarks
We searched the primary literature in PubMed, Embase and SciELO from inception to June 2025, using the terms diabetes, type 2 diabetes mellitus, glucagon-like peptide-1, L-cell, metabolic surgery, jejunostomy, GLP-1 receptor agonists as well as their combinations
Nature 599 , 650656 (2021)