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In addition, 1,25(OH)2D3 induces the release of neurotrophin and synthesis of Ca 2+ -binding proteins such as parvalbumin, inhibits the synthesis of inducible iNOS, macrophage colony-stimulating factor, TNF-, down-regulates L-type voltage sensitive Ca 2+ channel (LVSCC), and upregulates -glutamyl transpeptidase activity, which are also reported to be the potential neuroprotective mechanisms of VD in PD (Figure 2A) (9193)
Some protocols recommend splitting this dose into morning and evening administration for sustained effect
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