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The C-terminal amidation is critical for full biological activity, as the free-acid form shows significantly reduced receptor binding
Yonsei Med J 50(2):215221
This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles
doi: 10.1038/s41467-022-33797-6 141 IshiiTHattoriKMiyakawaTWatanabeKHideseSSasayamaDet al
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