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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

These observed sex-dependent differences have been attributed to sex-dependent metabolic alterations such as the estrogen-dependent synthesis of phosphatidylcholines 88,89,90,91