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TRIUMPH-4 (NCT05931367): 68-week standalone knee osteoarthritis trial, adults with obesity/overweight without diabetes (N=445, randomized 1:1:1 to 9mg, 12mg, or placebo)

Tirzepatide, a dual GIP/GLP-1 receptor agonist, has a slightly different receptor activity profile and may be tolerated differently, though gastrointestinal side effects remain common